Simulating Patient-Specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques
Simulating Patient-specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques – The vast majority of heart attacks occur when there is a sudden rupture of plaques, so-called vulnerable plaques, forming clots that can cause blockages in coronary arteries. The objective of the researchers’ work was to develop a computational tool-set to support the design and analysis of a catheter-based local nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. The goal is to rationally design drug-encapsulated nanoparticles in conjunction with patient-specific attributes and deliver drug locally to the diseased arteries, thereby personalizing and optimizing therapeutic intervention. To that end, a three-dimensional mathematical model of coupled transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis using the Texas Advanced Computing Center’s (TACC) HPC resources. The visualization component of this project, a 14 minute animation, seeks to explain the motivation of the research, the physical mechanism of the proposed solution concept, the mathematical models used, the computational methodology applied for simulation, and the scientific visualization of the results. Researchers Shaolie Hossain, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Thomas JR Hughes, PhD Institute for Computational Engineering and Sciences (ICES) The University of Texas at Austin Visualization and video production Ben …
Five Years Ago, a Dallas Compounding Pharmacy's Mistake Killed Three People …
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Osborn is a licensed pharmacist, and ApotheCure is licensed as a compounding center and pharmacy, but the AG's suit claimed they were operating outside the bounds of Texas law. The company was manufacturing drugs that weren't approved by the FDA …
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Gilda's Club name change insult to late comedian?
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In an ambitious road map for slashing the global spread of AIDS, the Obama administration says treating people sooner and more rapid expansion of other proven tools could help even the hardest-hit countries begin… In an ambitious … Haiti and the …
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Addiction counselor charged with murder in DUI
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… and author Zig Ziglar has died in Texas. He was 86.>> Motivational speaker Zig Ziglar, who wrote more than 30 books on living a balanced life, has died in Texas. He was 86. …. She attended Loyola Marymount University, where she was enrolled in an …
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M.D. Anderson intensifies its mission to fight cancer
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There is more to be learned about each patient's cancer and their defense mechanisms if we are to understand how to administer the most effective treatment. We also need to better understand how to choose optimal targets for drug development, as well …
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